The 2005 NFL Draft was held April 23-24 at the Jacob Javits Convention Center after moving from the Theater at Madison Square Garden in New York City. This was the only year the draft was held at the Javits Center.

A total of 255 players were selected. The most popular position among draftees was defensive back, with 50 selected. The school with the most players selected was Oklahoma with 11. A total of 38 underclassmen were drafted, the most of any draft year to that point. Four underclassmen were picked in the Top 10, the fewest since four were selected in 2000.

Utah QB Alex Smith was the No. 1 overall pick by the 49ers. Smith went 2-5 as a starter, as a rookie, but finished with one touchdown and 11 interceptions.

Maryland linebacker Shawne Merriman, selected 12th overall by the Chargers, was the Defensive Rookie of the Year. Auburn RB, Carnell "Cadillac" Williams, selected No. 5 overall by the Bucs, was the Offensive Rookie of the Year.

Texans kick returner Jerome Mathis, drafted 114th overall by the Texans out of Hampton University, was the only drafted player to be selected All-Pro as a rookie.

Oklahoma quarterback Jason White, the 2003 Heisman Trophy winner, was not selected. He was the first Heisman Trophy Winner since Charlie Ward ('93) to go undrafted.

"Mr. Irrelevant" was Andy Stokes, a tight end from William Penn, selected 255th overall by the Patriots. Notable among the late-round picks was USC quarterback Matt Cassel, selected in the seventh round, 230th overall, by the Patriots.