The 2000 NFL Draft was held April 15-16 at the Theater at Madison Square Garden in New York City. There were a total of 254 players selected over two days of the draft.

There were 52 defensive backs drafted, the most frequently-drafted position. Tennessee had nine players drafted, most of any school. The SEC had 41 players picked, most of any conference.

Penn State defensive end Courtney Brown was the first player selected by the Cleveland Browns. He was the first defensive end picked No. 1 since Bruce Smith in 1985, and the third defensive end to be picked first in the past 25 years (Lee Roy Selmon, 1976 Buccaneers).

Running back Mike Anderson of Utah, picked 189th overall (23rd pick of the sixth round) by the Broncos, was the Offensive Rookie of the Year. He is the lowest selected player to win Offensive Rookie of the Year

New Mexico linebacker Brian Urlacher, picked No. 9 overall by the Bears, was the Defensive Rookie of the Year.

Punter Shane Lechler, drafted 142nd overall by the Raiders, was the only drafted player to make All-Pro in his first season. He was a first-team choice.

Among the notable late-round selections in this draft was Michigan quarterback Tom Brady, drafted 199th overall (sixth round, 33rd pick) by the Patriots.

Northwestern State (Louisiana) defensive back Mike Green was "Mr. Irrelevant," the 254th and final pick.