A total of 27 underclassmen were drafted out of 35 who declared, matching the 1997 draft for most underclassmen selected.
The first three players selected were quarterbacks - Kentucky's Tim Couch (Browns), Syracuse's Donovan McNabb (Eagles), and Oregon's Akili Smith (Bengals). They were among 13 quarterbacks selected overall, 12 of whom played in the NFL. 1999 marked the second straight year that a quarterback was selected No. 1 (Peyton Manning, 1998 Colts).
No. 4 pick, Miami running back Edgerrin James (Colts) was the Offensive Rookie of the Year. The 16th overall pick, Florida defensive end Jevon Kearse, was named Defensive Rookie of the Year. Both were All-Pro first-team selections.
Among the most notable moves in the draft was the Saints trading their entire allotment of draft picks (six total) and two picks in the 2000 draft for the No. 5 pick, which was used to select Texas running back Ricky Williams.
Florida and Ohio State each had eight players drafted, most among any school. The SEC had 37 players selected, most by any conference.
The 253rd and final pick (Mr. Irrelevant) was Penn running back Jim Finn. He played 106 games and scored one touchdown in a seven-year NFL career.