The 1998 NFL Draft was held April 18-19 at the Theater at Madison Square Garden in New York City. A total of 241 players were selected over two days.

The most popular position among draftees was defensive back, with 43 selected. Washington had the most players drafted, with 10, one more than Florida State.

Tennessee quarterback Peyton Manning was selected by the Colts with the No. 1 overall pick. He was the first quarterback selected No. 1 overall since Drew Bledsoe was selected No. 1 by the Patriots in 1993. It was the third time since the AFL-NFL merger in 1970 that the Colts took a quarterback No. 1, with the others being John Elway (1983) and Jeff George (1990).

Though only eight quarterbacks were selected, quarterbacks went 1-2 overall, as the Chargers selected Washington State quarterback Ryan Leaf with the No. 2 pick. Leaf's career lasted 25 games, as he finished with 14 career touchdowns and 36 interceptions.

The Offensive Rookie of the Year was wide receiver Randy Moss, drafted No. 21 from Marshall by the Vikings. Moss was a first-team All-Pro selection as a rookie. Charles Woodson, selected No. 4 overall from Michigan by the Raiders, was the Defensive Rookie of the Year.

Among the notable late picks was Arizona State defensive back Pat Tillman, selected 226th overall by the Arizona Cardinals. Tillman left the NFL in 2002 to join the Army and was killed in Afganistan on April 22, 2004.

Among the notable undrafted players was linebacker London Fletcher, who played at Division III John Carroll University. Fletcher was a starter for the 1999 Super Bowl champion St. Louis Rams.

Weber State tight end Cam Quayle was "Mr. Irrelevant," the final player selected in the draft, by the Baltimore Ravens.