The 1995 NFL Draft was held April 22-23 at the Theater at Madison Square Garden in New York City. It was the first time the draft was held at MSG, after moving from the Marriott Marquis Hotel. A total of 249 players were selected over two days.

Colorado and Florida State each had 10 players selected, most of any school. The Big Ten was the conference with the most players drafted, 37, one more than the Pac 10.

The Carolina Panthers and Jacksonville Jaguars, both expansion teams heading into the 1995 season, were a part of the NFL Draft for the first time. Carolina was given the No. 1 pick and Jacksonville was No. 2. The Jaguars picked No. 1 in the expansion draft, one pick ahead of Carolina.

Penn State running back Ki-Jana Carter was the No. 1 overall pick by the Bengals. Cincinnati traded the No. 5 pick and No. 36 pick to Carolina for the No. 1 overall pick. Carter tore his ACL in his first preseason game and never rushed for more than 464 yards in a season, and finished with 1,144 career rushing yards.

Pittsburgh running back Curtis Martin, drafted 74th overall (third round) by the Patriots, was the Offensive Rookie of the Year. Central State (Ohio) defensive end Hugh Douglas, drafted 16th overall by the Jets, was the Defensive Rookie of the Year.

Among the notable late-round picks was Georgia running back Terrell Davis, drafted 196th overall by the Broncos. Davis rushed for 1,000+ yards in each of his first four seasons, including 2,008 yards in 1998, and won two Super Bowls with the Broncos.

Michael Reed, a defensive back from Boston College, was the 249th and final pick, also known as Mr. Irrelevant.