The 1991 NFL Draft was held April 21-22 at the Marriott Marquis Hotel in New York. A total of 334 players were selected over the two days.

Miami defensive tackle Russell Maryland was the No. 1 pick by the Cowboys. He was the second defensive tackle drafted first overall since 1968, the first since the Patriots drafted Texas defensive tackle Kenneth Sims first in 1982.

Arizona State running back Leonard Russell, drafted 14th by the Patriots, was the Offensive Rookie of the Year. Nebraska linebacker Mike Croel, drafted No. 4 overall by the Broncos, was the Defensive Rookie of the Year.

Among the notable players selected after the first round were Southern Mississippi quarterback Brett Favre, who was drafted 33rd overall by the Falcons. Two players of note were drafted in the 12th round -- 1995 Super Bowl MVP, cornerback Larry Brown (Texas Christian University), 320th overall, by the Cowboys, and UNLV wide receiver Kennan McCardell, 326th overall from UNLV, by the Redskins. McCardell had 883 receptions in a 16-season NFL career.

John Carroll (Division III) of Ohio quarterback Larry Wanke was "Mr. Irrelevant," the 334th and final player selected.