The 1989 NFL Draft was held April 30-May 1, 1989 at the Marriott Marquis Hotel in New York City. The draft consisted of 12 rounds and 335 selections.

The Dallas Cowboys had the first overall selection and chose UCLA quarterback Troy Aikman. Despite choosing a quarterback first overall, Dallas also exercised a 1990 first-round selection to chose Miami (FL) QB Steve Walsh in the 1989 Supplemental Draft.

Oklahoma State RB Barry Sanders, the 1988 Heisman Trophy winner, was selected third overall by the Detroit Lions and won Offensive Rookie of the Year. The Defensive Rookie of the Year was Chiefs LB Derrick Thomas, selected fourth overall out of Alabama.

As of 2009, Aikman, Sanders and Thomas have all been inducted into the Pro Football Hall of Fame.