In the 2008 season, the Bills finished 7-9 in the regular season, finishing in last place in the AFC East.
The Bills have used four of their last six first-round selections on defensive players, including 2008, when they chose Troy cornerback Leodis McKelvin. Prior to 2009, the last time they made two first round selections in the same draft was 2006, when they chose Ohio State DB Donte' Whitner (8th overall) and NC State defensive tackle John McCargo (26th overall).
- The Bills acquired the 19th pick in the 2nd round (51st overall) from the Dallas Cowboys in exchange for the 11th pick in the 3rd round (75th overall) and the 10th pick in the 4th round (110th overall) on April 25, 2009.
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