In the 2008 season, the Colts finished 11-5 in the regular season, finishing in second place in the AFC South. They lost to the San Diego Chargers in the AFC Wild Card Playoffs. This is their first draft under new head coach Jim Caldwell, who replaced Tony Dungy in January.
The Colts have used four of their last five first-round selections on offensive players. They did not make a first round selection in 2008.
- The Colts acquired the 13th pick in the 7th round (222nd overall) from the Philadelphia Eagles in exchange for a 6th-round pick in 2010 on April 26, 2009.