Matthews earned Rookie of the Week honors in Week 6, recording 2.0 sacks against the Detroit Lions. He earned the award again in Week 10, recovering two fumbles against the Dallas Cowboys. In Week 13, Matthews earned NFC Defensive Player of the Week honors, recording six total tackles, 2.0 sacks and a forced fumble in a win over the Baltimore Ravens.
Matthews finished his rookie season with 51 total tackles and 10.0 sacks, a Packers rookie record. He was added to the 2010 Pro Bowl roster, replacing Bears LB Lance Briggs.
Clay Matthews III also has two brothers who have played college football. His older brother, Kyle, played at USC from 2000-03, and his younger brother, Casey, is a linebacker at Oregon.